Setsuna SAKURAZAKI and Konoka KONOE from Mahou Sensei Negima.
They always make quite a nice duo: innocence, protective and yuri. I'm still surprised that they didn't end up conjoined in the manga (with all that magic stuff).
As a conjoined nurse, I'd love to go to the hospital they're workign in ^_^ hehehe
Have to say i'm not quite satsified with their final look...maybe the Uncanny Valley effect?